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Keep track of Carefully (1)phenobarbital will lessen the level or impact of fentanyl transmucosal by influencing hepatic/intestinal enzyme CYP3A4 metabolism. Modify Therapy/Monitor Carefully. Coadministration of fentanyl with CYP3A4 inducers may lead to some reduce in fentanyl plasma concentrations, deficiency of efficacy or, potentially, growth of

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